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Squidgy Black

To cel­eb­rate the long-​​awaited return of Coffeesh0p’s Squidgy Black incense, I thought I’d share a nice high res­ol­u­tion pho­to­graph of it (click to enlarge):

Squidgy Black

(Until 3 PM tomorrow (Monday after­noon), we’re giving away 1g samples with all orders over £30)

Posted in Internet Marketing | Tagged coffeesh0p, incense, legal highs, Squidgy Black |

Ivory Wave Destined For Class B

Or at least that’s how the media will inev­it­ably sim­plify it for all you plebs out there, who couldn’t pos­sibly need to know, let alone under­stand, the exact wording of the law. On the 13th of September, everyone’s favourite council of advisors, the Advisory Council on the Misuse of Drugs (ACMD) released their report on Desoxypi­pra­drol (2-​​DPMP), including advice for another broad ana­logue ban similar to the bans of the cath­inones & can­nabin­oids in the not too distant past.

Here’s the first part of the report, formatted and presented in lovely HTML (Annex 2 will be posted up soon.):

Consideration of Desoxypipradrol (2-DPMP) and related pipradrol compounds

Letter To The Home Secretary From The ACMD

13th September 2011Dear Home Secretary,

I write further to my cor­res­pond­ence of 29 October 2010 in rela­tion to the com­pound desoxypi­pra­drol (2-​​diphenylmethyl-​​piperidine, 2-​​DPMP). In its advice the Advisory Council on the Misuse of Drugs (ACMD) recom­mended that desoxypi­pra­drol, iden­ti­fied in samples of a product known as „Ivory Wave?, should be subject to an imme­diate ban under the Open General Import Licence. This advice was accepted by the Gov­ern­ment and a ban was imple­mented on 4 November 2011.

The ACMD has con­sidered the avail­able evid­ence and can now provide you with sub­stantive con­sid­er­a­tion of the com­pound desoxypi­pra­drol and its related com­pounds. A short report is annexed to this letter.

The National Poisons Inform­a­tion Service in Edin­burgh high­lighted that a number of indi­viduals had presented to the Royal Edin­burgh Infirmary in the summer of 2010 fol­lowing use of desoxypi­pra­drol with symp­toms that were similar to amphet­amine tox­icity, but with pre­dom­inant neuro­psy­chi­atric fea­tures including:

  • Hal­lu­cin­a­tions
  • Para­noia
  • Severe Agit­a­tion

In some cases these effects per­sisted for several days after ingestion.

In the attached report the ACMD has con­sidered the avail­able evid­ence from forensic pro­viders, the National Pro­gramme on Sub­stance Abuse Deaths, Clin­ical Tox­ic­o­logy Ser­vices, sci­entific research and Gov­ern­ment Depart­ments on the harms and sales of desoxypipradrol.

The ACMD advises that the harms of desoxypi­pra­drol are com­men­surate with other Class B drugs and recom­mend that it is con­trolled under the Misuse of Drugs Act 1971 as a Class B sub­stance and in Schedule 1 of the Misuse of Drugs Reg­u­la­tions 2001 (as amended). In addi­tion, the ACMD recom­mends that the struc­tur­ally related com­pounds diphen­yl­pro­linol (diphenyl-​​2– pyrrolidinyl-​​methanol, D2PM) and its desoxy form 2-​​diphenylmethylpyrrolidine are con­trolled under the Misuse of Drugs Act 1971 as Class B sub­stances and sched­uled under the Misuse of Drugs Reg­u­la­tions 2001. The pro­posed generic defin­i­tion will ensure that desoxypi­pra­drol and all its related com­pounds, e.g. diphen­yl­pro­linol and diphen­yl­methyl­pyrrolidine, are fully cap­tured (see Annex 1 & 2). The ACMD under­stands that desoxypi­pra­drol and its related com­pounds do not have any medi­cinal uses; however, the ACMD has not form­ally con­sulted with the industry.

The ACMD believes that there would be no con­flicting issues with placing the generic defin­i­tion in the Act as the three main drugs, desoxypi­pra­drol, diphen­yl­pro­linol (D2PM) and 2-​​diphenylmethylpyrrolidine can all be ana­lyt­ic­ally dis­tin­guished from one another and from other drugs in Schedule 2 Part II.

The pos­i­tional isomers of pipra­drol (diphenyl-​​2-​​piperidinemethanol), i.e. the diphenyl-​​3-​​piperidinemethanol and diphenyl-​​4– piperid­ine­meth­anol isomers would be Class B and in the absence of ref­er­ence stand­ards may not be readily dis­tin­guished from pipra­drol (Class C) using routine methods of ana­lysis (medi­cinal products con­taining pipra­drol are no longer widely used and are not, as far as the ACMD are aware, avail­able in the UK). Whilst, it should be pos­sible to dis­tin­guish between pipra­drol isomers using tech­niques such as NMR, in the long term it would be support forensic ana­lysis to have ref­er­ence stand­ards of all the pipra­drol pos­i­tional isomers.

The ACMD recom­mends that the Home Office con­siders com­mis­sioning the pro­duc­tion of stand­ards through the Forensic Early Warning System.

Yours sin­cerely,

Pro­fessor Les Iversen FRS

(cc: Anne Milton – Par­lia­mentary Under Sec­retary of State, Depart­ment of Health)

1. Background

In October 2010 the ACMD recom­mended to the Gov­ern­ment that, 2– diphenylmethyl-​​piperidine (2-​​DPMP, here referred to as desoxypi­pra­drol), which was being mar­keted at that time as “Ivory Wave”, should be subject to an imme­diate ban under the Open General Import Licence (OGIL). This advice was accepted by the Gov­ern­ment and a ban was imple­mented on 4 November 2011

Pub­lished data on the effects of 2-​​DPMP are limited, although research on deriv­at­ives of desoxypi­pra­drol show that they exhibit a cocaine-​​like binding profile (Schmitt et al., 2008).

Cur­rently, there is no known medi­cinal use for this com­pound, although it was ori­gin­ally developed by Ciba-​​Geigy (Novartis) in 1953 to be used to wake patients fol­lowing anaes­thesia (Belucci, 1955).

Desoxypipradrol & Pipradrol

This com­pound is related to pipra­drol, a previously-​​licensed medi­cine for treat­ment of Atten­tion Deficit Hyper­activity Dis­order (ADHD), obesity and nar­co­lepsy. Pipra­drol is clas­si­fied under the Misuse of Drugs Act as a Class C sub­stance. Pipra­drol still used is some coun­tries, but its use is limited due to its abuse poten­tial; it is a dopamine and nore­pineph­rine reup­take inhibitor.

Pipra­drol and its desoxy form have struc­tur­ally related pyrrolidine ana­logues (see below) such as diphen­yl­pro­linol (diphenyl-​​2-​​pyrrolidinylmethanol, D2PM), for which there have been a number of recorded cases of car­di­ovas­cular and neuro­psy­chi­atric tox­icity asso­ci­ated with recre­ational use (Lidder et al., 2008, Wood et al., 2008, Wood et al., 2011), and 2-​​diphenylmethyl-​​pyrrolidine, cur­rently mar­keted, along with D2PM and various ana­logues, as chem­ical reagents for use as chiral cata­lysts in organic syn­thesis (Ber­telsen et al., 2005, Sigma-​​Aldrich, 2007).

ß-phenylmethylamphetamine

The two pairs of mater­ials differ only by the size of the nitrogen-​​containing ring. Diphen­yl­pro­linol and its desoxy form have a five-​​membered (pyrrolidine) ring, while pipra­drol and its desoxy form have a six-​​membered (piperidine) ring. It seems that the two desoxy forms have par­tic­u­larly long-​​lasting effects as their struc­tures are res­istant to meta­bolism, meaning that they have longer half-​​lives in the body. A common feature of these com­pounds is that they are struc­tur­ally related to ß-phenyl­methyl­amphet­amine, which is also a potent stim­u­lant with a long half life. However, these com­pounds differ from ß-phenyl­methyl­amphet­amine in that the nitrogen atom is linked to the a– methyl group by two or three carbon atoms to form a ring.

Pipradrol Analogues

Various ana­logues of these com­pounds have been invest­ig­ated and found to have stim­u­lant prop­er­ties (Isbell, 1970 and US Patents). Simple modi­fic­a­tions, for example, addi­tion of halogen, alkyl or alkoxy groups on one or both of the phenyl rings or addi­tion of alkyl, alkenyl, haloalkyl and hydroxyalkyl groups on the nitrogen atom have been reported to produce com­pounds having a stim­u­lant effect on the CNS, which could lead to a range of “designer” forms.

Other modi­fic­a­tions that have been reported in the lit­er­ature include repla­cing the piperidine ring with an azepane ring (7-​​membered ring), a mor­pholine ring or a pyridine ring (Win­throp, 1961; Enyedy, 2003). The piperidine ring has also been mod­i­fied by sub­sti­tu­tion in the ring with an hydroxy group (Nodine, 1960), fusion of the piperidine ring with a benzene ring (Win­throp, 1961) and by sub­sti­tu­tion at the nitrogen atom with an ethano bridge to form a bicyclic ring system (Wiki­pedia, 2011).

Almost all of the ana­logues invest­ig­ated are struc­tur­ally related to the 2-​​isomer of desoxypi­pra­drol, with 2 carbon atoms between the phenyl rings and the nitrogen atom. The only excep­tions being the N–haloalkyl deriv­at­ives of desoxypi­pra­drol and the pyridine ana­logue in which the 2-​​, 3– and 4– isomers were all reported to be active. No examples were found of com­pounds related to 1-​​diphenylmethylpiperidine (N–diphen­yl­methyl– piperidine).

Whilst, it should be pos­sible to dis­tin­guish between pipra­drol isomers using tech­niques such as NMR, in the long term it would be support forensic ana­lysis to have ref­er­ence stand­ards of all the pipra­drol pos­i­tional isomers. The ACMD recom­mends that the Home Office con­siders com­mis­sioning the pro­duc­tion of stand­ards through the Forensic Early Warning System.

2. Use and prevalence

The National Poisons Inform­a­tion Service in Edin­burgh high­lighted that a number of indi­viduals had presented to the Royal Edin­burgh Infirmary in the summer of 2010 fol­lowing their use of desoxypi­pra­drol with symp­toms that were similar to amphet­amine tox­icity, but with pre­dom­inant neuro­psy­chi­atric fea­tures including:

  • Hal­lu­cin­a­tions
  • Para­noia
  • Severe Agit­a­tion

In some patients the symp­toms were still being mani­fested 5 – 7 days after inges­tion and some patients presented dir­ectly to psy­chi­atric ser­vices, bypassing A&E. There were approx­im­ately 12 cases over this period. It was sub­sequently reported that 4 out of 5 of the Edin­burgh cases in whom con­firm­atory tox­ic­o­lo­gical screening was carried out were pos­itive for desoxypi­pra­drol in urine/​blood con­firming exposure.

The number of patients presenting after con­firmed inges­tion of desoxypi­pra­drol after the summer of 2010 has dra­mat­ic­ally reduced in Edin­burgh with no cases in 2011 and data from the National Poisons Inform­a­tion Service (NPIS) sug­gests that there has also been a sig­ni­ficant reduc­tion nation­ally. However, as noted below cases of diphen­yl­pro­linol (D2PM) tox­icity con­tinue to occur.

So far 3 deaths have been linked to the use of desoxypipradrolb(awaiting final reports).

Data provided by the Home Office Centre for Applied Science and Tech­no­logy (CAST) under its Forensic Early Warning System (FEWS) reported one sample of 2-​​DPMP (from a head-​​shop), 10 samples of D2PM and 4 samples of desoxy-​​D2PM (from test pur­chases) during the pilot study.

LGC Forensics reported those samples of “Ivory Wave” it had seen in 2009 – 2011 con­tained dif­ferent active ingredi­ents including the cath­inone MDPV (methyl­e­ne­di­oxypyro­va­lerone) then, after this became con­trolled, naphyrone, and when this too was con­trolled, desoxypi­pra­drol. More recently, diphen­yl­pro­linol has begun to appear in “legal high” products.

Desoxypi­pra­drol has been found as a white powder that is gen­er­ally taken by nasal insuf­fla­tion (sniffing the powder into the nose) or swal­lowing after wrap­ping the powder in a cigar­ette paper (“bombing”) to avoid any unpleasant taste.

It is con­sidered that 2-​​DPMP and its related com­pounds, as cap­tured under the generic defin­i­tion (see recom­mend­a­tion), have poten­tial social harms. It appears to the ACMD that such harms are likely in rela­tion to the impair­ment of func­tion through drug use (mood dis­orders, changes to life­style), loss of rela­tion­ships and the poten­tial harm to others (dir­ectly and indirectly).

3. Preclinical Data

In the 1950’s, Ciba-​​Geigy invest­ig­ated the effects of desoxypi­pra­drol, amphet­amine and d-​​methylamphetamine on small animals (report kindly provided by Novartis). The LD50 is the dose, which kills 50% of the animals:

Table 1. Tox­icity of desoxypi­pra­drol and other com­pounds, meas­ured as LD50, to small animals.

Desoxypi­pra­d­rol
LD50 g/​kg
Amphet­am­ine
LD50 g/​kg
D-​​methylamphetamine
LD50 g/​kg
Mouse iv*0.0200.0500.020
” sc0.0470.0600.080
” po0.0500.0700.150
Rat iv0.0150.0120.023
” sc0.0300.0120.015
” po0.0800.0130.025
Rab­bit iv0.0060.0400.030
” sc0.0070.0450.020
” po0.0800.1700.200

(*iv – intra­venous, sc – sub­cu­taneous, po – orally)Table 1 shows that desoxypi­pra­drol is, in many cases, more toxic than amphet­amine and d-​​methylamphetamine.

The Ciba-​​Geigy report (from the 1950s) also noted that desoxypipradrol:

pro­duced a marked central arousal in various, non-​​anaesthetised animals, con­sisting ini­tially of general agit­a­tion, sub­sequently a greater degree of increase in co-​​ordinated motility, heightened reflexes, com­pelled move­ments and rel­at­ively slight res­pir­atory stimulation.

This was easily dis­cern­ible object­ively in the normal mouse with the aid of the cage move­ment regis­tra­tion method. With this method the indi­vidual move­ments are registered dir­ectly and added up by means of a totaliser.

Figure 1. Effect­ive­ness of desoxypi­pra­drol in stim­u­lating activity in mice when when admin­istered sub­cu­taneously (heavy line) or orally (thin line)
(Figure repro­duced with kind per­mis­sion of Novartis)

The data show that desoxypi­pra­drol is effective as a stim­u­lant in doses com­par­able to those for amphet­amine or methyl­amphet­amine – from 1 mg/​kg upwards. For the pur­poses of its research at the time, Novartis recom­mended an initial human dose of 1mg or less, (ca 0.014 mg/​kg). Anec­dotal inform­a­tion would suggest that the human dose is only a few mg, with 10mg or more being con­sidered harmful.

Exper­i­mental data sup­plied by Dr Colin Dav­idson (St Georges, Uni­ver­sity of London, 2011) demon­strated that desoxypi­pra­drol potently stim­u­lated dopamine release from rat brain slices in vitro. Dopamine release was meas­ured from the region of the nucleus accum­bens, using carbon fibre micro­elec­trodes and fast cyclic voltam­metry to elec­tric­ally measure the oxid­a­tions of dopamine. The rate of recovery of stim­u­lated dopamine release also allowed meas­ure­ment of the action of the drug as an inhib­itor of the dopamine reup­take mech­anism. Dopamine release in the nucleus accum­bens is con­sidered to be a key target for psy­chos­tim­u­lant drugs.

Figure 2. Effect of desoxypi­pra­drol (10uM) on dopamine efflux in rat nucleus accum­bens

It also proved pos­sible to compare the potency of desoxypi­pra­drol with the psy­chos­tim­u­lant drug cocaine in the brain slice pre­par­a­tion. The results (Figure 3) indicate that desoxypi­pra­drol is both more effective and more potent than cocaine in stim­u­lating dopamine release and in inhib­iting its reuptake.

Figure 3. Com­par­ison of poten­cies of desoxypi­pra­drol and cocaine in releasing dopamine, and inhib­iting inac­tiv­a­tion in rat brain slice pre­par­a­tions (C. Dav­idson, unpub­lished)

The results both from Novartis and from Dr Dav­idson indicate that desoxypi­pra­drol is very potent and com­par­able to amphet­amine or methyl­amphet­amine in its poten­tial to cause acute toxicity.

The avail­able human data also show it to be a long-​​lasting sub­stance, capable of eli­citing agit­a­tion lasting for several days after a single dose.

In addi­tion to the reports of tox­icity asso­ci­ated with the use of desoxypi­pra­drol noted above, there have also been reports of sig­ni­ficant tox­icity asso­ci­ated with the recre­ational use of the related com­pound diphen­yl­pro­linol (D2PM). In addi­tion, reports from forensic pro­viders suggest that D2PM has replaced desoxypi­pra­drol in many “Ivory Wave” products. The clin­ical tox­ic­o­logy service at Guy’s and St Thomas’ Hos­pital in London have doc­u­mented 6 cases of ana­lyt­ic­ally con­firmed D2PM tox­icity: 1 case in 2008 and 5 cases in 2010 /​ 2011 (Lidder et al., 2008, Wood et al., 2008, Wood et al., 2011). In these cases patients have presented with a variety of symp­toms including:

  • chest pain
  • agit­a­tion
  • anxiety
  • insomnia
  • hal­lu­cin­a­tions
  • para­noia

In many of these cases patients have had ongoing fea­tures, in par­tic­ular neuro-​​psychiatric fea­tures such as anxiety, insomnia and para­noia for up to 48 – 96 hours after use of D2PM.

4. Recommendation

The ACMD advises that the harms of desoxypi­pra­drol are com­men­surate with other Class B drugs and recom­mend that it is con­trolled under the Misuse of Drugs Act 1971 as a Class B sub­stance and in Schedule 1 of the Misuse of Drugs Reg­u­la­tions 2001 (as amended). Fur­ther­more, we recom­mend that the struc­tur­ally related com­pounds diphen­yl­pro­linol (diphenyl-​​2-​​pyrrolidinyl-​​methanol, D2PM) and its desoxy form 2-​​diphenylmethylpyrrolidine are sim­il­arly con­trolled under the Misuse of Drugs Act 1971 and sched­uled under the Misuse of Drugs Reg­u­la­tions 2001 by virtue of a generic defin­i­tion (see Annex 1 of the report) to ensure that desoxypi­pra­drol and related com­pounds, e.g. diphen­yl­pro­linol, diphen­yl­methyl­pyrrolidine, are fully cap­tured (see Annex 1 & 2).

The ACMD under­stands that desoxypi­pra­drol and its related com­pounds do not have any medi­cinal uses; however, the ACMD has not form­ally con­sulted with the industry.

The pro­posed generic defin­i­tion includes desoxypi­pra­drol and those ana­logues most likely to be pro­duced as altern­at­ives. Some of the com­pounds that fall within the scope of the pro­posed generic defin­i­tion contain a hydroxy group, which can be con­verted to an ester or ether. Such com­pounds may have similar phar­ma­co­lo­gical prop­er­ties to the parent com­pound and there­fore it is recom­mended that esters and ethers of these com­pounds are also subject to control under the Misuse of Drugs Act, 1971.

Whilst, ideally, any generic defin­i­tion would include all pos­sible pos­i­tional isomers, this may mean that non-​​active com­pounds would also be con­trolled. Further, a defin­i­tion to cover all of these poten­tial ana­logues is feas­ible, but it would be very complex and pos­sibly dif­fi­cult to understand.

Under the defin­i­tion that the ACMD propose at Annex 1 esters and ethers of pipra­drol would not be con­trolled. This is because pipra­drol is spe­cific­ally excluded from the generic defin­i­tion and there­fore para­graph 2A would also not apply to pipra­drol. For con­sist­ency the ACMD advise the inclu­sion of esters and ethers of pipra­drol by moving pipra­drol from Schedule 2 Part III para­graph 1(a) to para­graph 1(b) so that para­graph 1(d) regarding esters or ethers would apply to pipradrol.

The ACMD further advise that ste­reoi­somers should be con­trolled by Schedule 2 Part II para­graph 2. The three main drugs, desoxypi­pra­drol, diphen­yl­pro­linol (D2PM) and
2-​​diphenylmethylpyrrolidine all have ste­reoi­somers and most of the com­pounds covered by the generic defin­i­tion will also have stereoisomers.

5. References

  1. Bel­lucci G. (1955); (2-​​Diphenylmethyl-​​piperidine hydro­chloride and the methyl ester of 2-chloro-2-phenyl-2-(2-piperidyl)-acetic acid), drugs with waking effect in anaes­thesia. Minerva Anestesiolo­gica 21: 125 – 8.
  2. Ber­telsen S, Halland N, Bach­mann S, Marigo M, Braunton A, Jør­gensen KA. (2005); Organocata­lytic asym­metric a-​​bromination of alde­hydes and ketones. Chem­ical Com­mu­nic­a­tions 4821 – 4823.
  3. Enyedy IJ, Sakamuri S, Zaman WA, Johnson KM, Wang S. (2003); Pharmacophore-​​based dis­covery of sub­sti­tuted pyridines as novel dopamine trans­porter inhib­itors. Bioor­ganic & Medi­cinal Chem­istry Letters;13:513 – 517.
  4. Hoff­mann K, Heer J. (1958); 2-​​Diphenylmethyl-​​piperidine com­pounds. US Patent 2,826,583.
  5. Hoff­mann K, Heer J. (1958); Piperidines and their man­u­fac­ture. US Patent 2,849,453.
  6. Hoffman K. (1962); 1-​​Ethyl-​​2-​​diphenylmethyl-​​piperidines. US Patent 3,048,594.
  7. Hoff­mann K, Heer J. (1960); Sub­sti­tuted 2-​​diphenylmethyl-​​piperidine com­pounds. US Patent 2,957,879.
  8. Isbell H, Chrus­ciel TS. (1970); Depend­ence Liab­ility of Non-​​Narcotic Drugs. Bul­letin of the World Health Organ­isa­tion; 43: Sup­ple­ment, pages 76 – 77.
  9. Lidder S, Dargan P, Sexton M, Button J, Ramsey J, Holt D, Wood D. (2008); Car­di­ovas­cular tox­icity asso­ci­ated with recre­ational use of diphen­yl­pro­linol (diphenyl-​​2-​​pyrrolidinemethanol [D2PM]). Journal of Medical Tox­ic­o­logy; 4(3):167 – 9.
  10. Nodine JH, Bodi T, Slap J, Levy HA, Siegler PE. (1960); Pre­lim­inary trial of a new stim­u­lant SCH 5472 in ambu­latory patients with depres­sion, exhaus­tion, or hyper­somnia syn­drome. Anti­bi­otic Medi­cine and Clin­ical Therapy ; 7:771 – 6.
  11. Novartis (1955) Inform­a­tion on Prep. No. 14?469 (desoxypi­pra­drol), a new syn­thetic stim­u­lant with central point of application.
  12. Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith ME. (2008); Inter­ac­tion of cocaine-​​, benztropine-​​, and GBR12909-​​like com­pounds with wild-​​type and mutant human dopamine trans­porters: molecular fea­tures that dif­fer­en­tially determine antagonist-​​binding prop­er­ties; Journal of Neuro­chem­istry 107: 928 – 40.
  13. Sigma-​​Aldrich Co. (2007) “Organocata­lysis”, Chem­istry files, vol 7, No.
  14. Wiki­pedia entry for AL-​​1095. <http://​en​.wiki​pedia​.org/​w​i​k​i​/​A​L​-​1​095>; 2011 [accessed 25.08.11].
  15. Win­throp SO. (1960) a-(3-Morpholyl)-benzhydrol and its salts. US Patent 2,947,749.
  16. Win­throp SO. (1961); 3-​​Benzhydrylmorpholine and salts thereof, and method of pre­paring said com­pounds. US Patent 2,993,895.
  17. Win­throp SO, Humber LG. (1961); Central Stim­u­lants. Cyc­lized Diphen­yl­iso­p­ro­pyl­am­ines. Journal of Organic Chem­istry 26: 2834 – 6.
  18. Wood DM, Davies S, Puchnarewicz, Holt DW, Dargan PI. A case series of indi­viduals with ana­lyt­ic­ally con­firmed acute diphenyl-​​2– pyrrolid­ine­meth­anol (D2PM) tox­icity. Manu­script sub­mitted for publication.
  19. Wood DM, Puchnarewicz M, Holt DW, Ramsey J, Dargan PI. (2011); Detec­tion of the pre­cursor ben­zo­phenone in indi­viduals who have used legal highs con­taining diphenyl-​​2-​​pyyrrolidinemethanol (D2PM). Basic & Clin­ical Phar­ma­co­logy & Tox­ic­o­logy; 109 (Suppl. 1): 86.

Annex 1

Proposed generic definition

Any com­pound (not being pipra­drol) struc­tur­ally derived from piperidine, pyrrolidine, azepane, mor­pholine or pyridine by sub­sti­tu­tion on a ring carbon atom with a diphen­yl­methyl group, whether or not the com­pound is further mod­i­fied in any of the fol­lowing ways, that is to say,

  1. by sub­sti­tu­tion in any of the phenyl rings to any extent with alkyl, alkoxy, haloalkyl or halide groups;
  2. by sub­sti­tu­tion on the methyl carbon atom with an alkyl, hydroxyalkyl or hydroxy group;
  3. by sub­sti­tu­tion on the ring nitrogen atom with an alkyl, alkenyl, haloalkyl or hydroxyalkyl group.

Posted in Drugs, Legislation |

New Coffeesh0p Logo

While this blog might be getting nice new design in the next few days, Coffeesh0p is being com­pletely over­hauled with a tonne of new fea­tures, as awesome as they are numerous. I’ll have to detail them all at some point, whether here or on a news post on the site itself, but for now click this link for a little preview of the new logo (Warning: inter­act­ively funky):

–> Coffeesh0p’s New Logo <–

Please leave any feed­back in the com­ments below.

Posted in Internet Marketing, Synchronium | Tagged coffeesh0p |

A Kick Up The Arse

Right. This blog, and myself, need a kick up the arse. The best way for that to happen is for me to give it a bit of a facelift, as now it looks like a faded book that’s sat on the shelf in direct sun­light for a few years.

The problem is, I’m crap at designing stuff. I love the thought of designing, but I always end up com­bining every single style I think looks good into some big cas­serole of a layout. So to force myself to not do that, I need a bit of help from you.

If you could please leave a comment with two or three words to describe the blog, that would be awesome. As I have no  idea how other people per­ceive this site, I think finding out would be a useful first step, then I can work on designing some­thing around a couple of those themes.

So, if you wouldn’t mind…

Posted in Synchronium |

Weed Maths

Plot the graph of this equation:

And this is the result:

 

 

I bet René Descartes is rolling in his grave.

Posted in Drugs | Tagged maths, weed |

How To Light A Cigar Underwater

 

Or at least, how to light a cigar under some kind of awesome cocktail!

The wife & I have just got back from the Domin­ican Republic where we cel­eb­rated our first anniversary. Got tonnes more work to do though, but I’ll try and update this blog again soon!

Posted in Miscellaneous | Tagged cigars, jokes |

The Best Clip Ever

I just pissed my pants for about 15 entire minutes at the 30 second clip from Family Guy. We imme­di­ately rewatched it during the episode a good three or four times, if only because we missed the pre­vious reply laughing like a pair of bas­tards.

Watch it Immediately.

Posted in Miscellaneous | Tagged Family Guy, Stoned TV, terrorism |

The US & Harm Reduction

This post has been robbed in its entirety with per­mis­sion from the always-​​eloquent Neuro­bonkers.

newly leaked cable exposes the intense inter­na­tional pres­sure the United States placed on the United Nations to block the suc­cessful drug harm reduc­tion strategies we have in Europe. The sci­entific facts are astound­ingly clear regarding this issue. Harm reduc­tion is a par­tic­u­larly serious issue because it does not only save the lives of drug users but pre­vents the spread of HIV. Due to our strategies of harm reduc­tion such as meth­adone pro­grammes and needle exchanges for intra­venous drug users Europe has some of the lowest HIV rates in the world. America and Russia have the worst HIV rates in the developed world because both of these coun­tries do not prac­tice harm reduc­tion meas­ures. This message is par­tic­u­larly serious coming from the US because according to US law items which prevent HIV being trans­mitted are not only denied to health author­ities but they are actu­ally illegal to possess, there­fore pushing harm reduc­tion char­ities such as needle exchanges under­ground. If this were to happen here we would see levels of HIV sky-​​rocket towards the appalling levels seen in the United States and Russia. If this is not wor­rying enough the rhet­oric being used to support the US strategy is frankly sick­ening. The rhet­oric is that the more dan­gerous drug taking is, the less people will take drugs. The fact that this results in count­less unne­ces­sary deaths and trans­mis­sion of HIV which would oth­er­wise be com­pletely pre­vent­able is not considered.

In the cable the European standard of harm reduc­tion is described as an “EU Crusade on Harm Reduc­tion” (sic). The irony here is on a number of levels. Firstly, a “crusade” is a war based on the impos­i­tion on moral/​religious values. The US is con­ducting a crusade based on the mor­ality of drug abuse yet it is the US however who are accusing Europe of a “crusade on harm reduc­tion”. Secondly, this is clearly not a European crus­dade on harm reduc­tion, perhaps it could con­ceiv­ably be a crusade for harm reduc­tion but def­in­itely not on harm reduc­tion. Thirdly, assuming that is what they meant, a “crusade for harm reduc­tion” is perhaps the most poet­ic­ally, para­dox­ic­ally absurd descrip­tion of a basic health care prin­ciple I’ve ever heard. Fourthly, it is pat­ently obvious that it is the US and not Europe who is actu­ally entering a “crusade on harm reduc­tion” namely because they are the only ones cru­sading in any way shape or form with regard to this issue. (Ok, so are the Rus­sians but they’re just as barmy). Finally, I hope I need not explain the final tragic irony of describing the imposing of a new morally driven blanket ban on a basic health care prin­ciple that stops the spread of HIV as a “crusade”. The ori­ginal cru­sades res­ulted in a still existing blanket ban on the primary barrier to HIV trans­mis­sion and this is of course, the main reason we have a global HIV crisis in the first place. My only con­clu­sion is that this wording was a failed attempt at very dark humour. Trust the Amer­icans to fail at irony. Damn, I’ve just pissed off both of the world’s largest super­powers and the world’s largest reli­gion in one fell swoop. Maybe we should keep the nukes afterall. At least nukes don’t give us AIDS.

Foot­note: The title of para­graph four of the leaked cable is “Is it EU Solid­arity or (the) UK Leading the Crusade?“. If the Amer­icans insist on calling life saving harm reduc­tion a crusade and sug­gesting it is us that are leading the charge then this is perhaps the first crusade in our history that we can actu­ally be proud of.

Addendum: Alan Clear, the dir­ector of The Harm Reduc­tion Coali­tion reported the actual events that res­ulted from this only now released cable…

“Would the UN Member States assemble a polit­ical declar­a­tion almost identical to the last one? The 1998 version dealt with drug demand reduc­tion by adopting what we now know to be the expensive, inef­fective, and dis­astrous law-​​and-​​order route that has cost the US alone 40 billion per year – without sig­ni­fic­antly redu­cing either supply or demand – and made us the world’s largest jailer of our own people.

…Or would this be the year that member states would move towards a public health and human rights approach to drug policy?…

…to reject the inclu­sion of the term “harm reduc­tion” in the Polit­ical Declar­a­tion being endorsed at this meeting is extremely short sighted and prob­lem­atic. It puts the US in the pos­i­tion of sitting in judg­ment of suc­cessful pro­grams being run by many coun­tries glob­ally; it also ignores the very suc­cessful use of harm reduc­tion in the United States to stem the tide of over­dose deaths, low threshold drug treat­ment and Hep­at­itis C treat­ment and care in major centers including New York City. Worst of all, it negates the sound science behind inter­ven­tions like safer injec­tion spaces or heroin pre­scrip­tion programs.

…This meeting is unfor­tu­nately timed. Whereas the new Obama admin­is­tra­tion is making steps to move in a more pro­gressive human rights based dir­ec­tion, the ground­work for the drafting of the Polit­ical Declar­a­tion has taken place with State Depart­ment employees who took their dir­ec­tion from the pre­vious admin­is­tra­tion and haven’t yet been presented with a new agenda. Sadly it will be another 10 years before there will be an oppor­tunity to revisit UN drug policy again.”

The full Leaked cable

 

Ref­er­ence IDCreatedReleasedClas­si­fic­a­tionOrigin
09UNVIEVIENNA312009-​​01-​​27 16:042011-​​04-​​28 00:12UNCLASSIFIED/​/​FOR OFFI­CIAL USE ONLYUNVIE

VZCZCXYZ0000
RR RUEHWEB
DE RUEHUNV #0031/01 0271621
ZNR UUUUU ZZH
R 271621Z JAN 09
FM USMISSION UNVIE VIENNA
TO RUEHC/SECSTATE WASHDC 8938
RUCNDT/USMISSION USUN NEW YORK 1453
RUEHBS/USEU BRUSSELS

UNCLAS UNVIE VIENNA 000031
SENSITIVE
SIPDIS
E.O. 12958:  N/A
TAGS: SNAR KCRM UN PGOV AORC UK CO RS JA CA FR SW GM
EI, IT
SUBJECT:  Breaking the UNGASS Impasse on "Harm Reduction"
REF:  A) UNVIE 00001, B) Tsai-Pala 1/23 email
¶1. (U) This is an action message for INL/PC and IO/T.  Please see
paragraph 7.
-------
Summary
-------
¶2. (SBU) Negotiations for the UNGA special session have hit an
impasse, created by EU insistence on adding the controversial term
"harm reduction" to various parts of the draft UNGASS action plan
and political declaration.  While Canada, an opponent of the term's
inclusion, is considering conceding to EU demands, other opponents
are standing firm with the U.S. in preventing such a problematic
element's inclusion.  Mission has engaged counterparts at every
level, from experts to ambassadors in an attempt to break the
impasse and find compromise language.  Mission believes there is
increasing pressure within the EU to resolve this gridlock and avoid
an embarrassing showdown at the March Commission on Narcotic Drugs
(CND) but some delegations will be inclined to hold this issue
hostage up until the opening of the CND, in hopes the US will
relent.  To facilitate EU compromise, Mission recommends that the
Department reach out to various capitals and the European Commission
to help underscore the firmness of U.S. resolve-both to our allies
and to the EU, before the EU horizontal group meeting in Brussels on
February 4.  Mission has urged like-minded countries here (Japan,
Russia, Colombia) to take similar actions.  End Summary.
------------------------------
EU Crusade on "Harm Reduction"
------------------------------
¶3.  (SBU) There have been difficult negotiations in Vienna on the
"harm reduction" issue in the demand reduction chapter of the draft
UNGASS action plan (Ref A) and political declaration.  The Czech
Republic reiterated this demand on January 26 on behalf of the
presidency.  The plan will be annexed to the political declaration
expected to be issued by ministers attending the high-level segment
of the UNGASS review meeting in Vienna March 10-12, 2009.  The main
divide is between EU advocates for including "harm reduction" in the
plan, and those who oppose such inclusion, namely U.S., Russia,
Japan, Colombia and possibly Canada.  Although opposed to harm
reduction, Canada's experts in Ottawa are receptive of a recent
compromise (including the term in a footnote rather than in the
text), and we understand that Ottawa will have a discussion on the
political level to decide how to handle this issue.
-----------------------
Is it EU Solidarity or
UK Leading the Crusade?
-----------------------
¶4. (SBU) Recent meetings to reach a compromise with EU had been
inconclusive.  The USG (United States Government) cannot accept including the specific term
"harm reduction" in any part of the action plan.  The USG also wants
the section to focus on "prevention, treatment and rehabilitation"
in the consideration of any demand reduction strategy.  The EU, on
the other hand, appears less concerned about treatment and
rehabilitation.  The EU presented a very hard-line position in the
opening rounds of these negotiations in mid-January.  Subsequently,
Mission conducted extensive consultations at all levels, including
between Ambassador and the DCM with their counterparts.  Mission's
conclusion is that the EU may not have a tightly united front.  The
UK is the primary and most vocal crusader on this issue, although
Netherlands does lend occasional support, as do Spain and the EC.
Importantly, other EU countries, initially implacable, appear to be
wavering (e.g., Germany).   Still others have expressed varying
degrees of flexibility, including France, Belgium, Ireland, and
Italy, as well as Sweden, which is closest to the U.S. position.
----------------------
Next Steps for Mission
----------------------
¶5. (SBU) Mission continues to engage with both skeptics and
proponents of "harm reduction."  To that end, Mission plans to
offer alternative language, previously sent to INL/PC (Ref B) at the
next informal consultations.  Mission's language is based on the
November 2008 UNGA resolution on international drug control
(A/63/432), which found consensus in New York.  Importantly, that
language was co-sponsored by 58 countries, including  the U.S. and
at least 7 EU countries.  Mission will propose inserting "care" into
the language as a way to address EU concerns.  U.S. proposed
language for paragraph 9 of the draft Action Plan, therefore, would
read,
 "Develop, review and strengthen, as appropriate, prevention,
treatment, care and rehabilitation of drug use disorders and to take
measures to reduce the social and health consequences of drug abuse
as governmental health and social priorities, in accordance with
international drug control treaties, and where appropriate, national
legislation."
(Note:  The 7 EU co-sponsors of the November 2008 UNGA resolution
are: Austria, Belgium, Czech Republic, Denmark, Ireland, Italy, and
Latvia.  End Note.)
¶6.  (SBU) Mission has shared this language with Japan, Russia, and
Colombia, as well as the CND chair Namibia, who is chairing the
current negotiations on the political declaration.  Offering this
language will allow Mission to more constructively engage the EU and
the chair of the working group (Iran) (who has taken a very active
role in trying to find consensus).  Although Iran chair had
originally scheduled another informal meeting for the afternoon of
January 27, Namibian ambassador told Missionoffs and their Japanese
and Russian counterparts the morning of January 27 that she would
announce the cancellation of that meeting until further notice.  She
said she had heard from many delegations that there should be a
"cool down" period on this issue.  According to her, many
delegations are opposed to the EU position, even though they did not
speak up on the floor.
¶7. (SBU)  Mission has suggested like-minded countries (Russia,
Japan, Colombia) to intervene at the ambassadorial level in Vienna.
We have also suggested that their capitals demarche relevant
countries.  Mission will also ask the G-8 chair in Vienna, the
Italian ambassador, to convene a meeting of the G-8 members to
underline the same.  By engaging EU member states in a different
context, it may help them to reevaluate their dogmatic and
unproductive approach.
-------------------
Recommended Actions
-------------------
¶8. (SBU)  Action Request:  The EU's horizontal group will have its
next coordination meeting on drugs in Brussels on February 4.  In
order to break EU unity on this issue, and thereby create a climate
in Vienna conducive to compromise, Mission recommends engagement
both with skeptics and supporters of the issue.  Specifically,
Mission recommends;
 (i)  Department instruct USEU to contact the European Commission's
horizontal group on drug control (Carol Edwards at the EC).
Instructions should note that the potential for embarrassment is
great for the EU, should the EU hold hostage an entire document
because of one sub-issue in one section of the action plan..
Mission believes that each passing week without compromise will add
increasing pressure within the EU to resolve this issue and prevent
embarrassment for national ministers planning to attend the CND.
Instructions should also note that the March CND will be the first
foray of the Obama administration into the international drug arena,
and all sides should be keen to make it a positive one.
(ii)  Department instruct U.S. Embassies Tokyo, Moscow, and Bogota
to reach out to host governments and emphasize our need to continue
supporting each other, as well as the firmness of U.S. resolve and
the continuity of our policy vis-`-vis "harm reduction."  It is
important that our allies on this issue remember that the burden is
on the EU, as the proponent of the term, to convince other
delegations-not the other way around.
(iii)  Department instruct U.S. Embassy Ottawa to persuade Ottawa at
a political level that it should at least consider remaining silent
on the EU proposal for the time being, and/or until the EU shows
more flexibility.  Although there is pressure in Vienna on all
delegations to commit to the EU proposal, Ottawa should remember
that there is no need to accede to hard-ball tactics, and that the
goal is for all sides to find common ground.
(iv)  Department instruct U.S. Embassy London to underscore the need
to find common ground.  Mission believes that UK's expert in Vienna
is a driving force behind the current EU approach, and that she may
find herself isolated within the EU as other delegations begin to
feel the urgency for compromise.
(v)  Department instruct U.S. Embassy Prague to reaffirm with the EU
presidency the importance of finding common ground.  Instructions
should note the importance the USG places on getting US-EU relations
off on the right foot, and that nothing related to the CND
jeopardizes that common goal. Instructions should also note that the
Czech Republic was one of the co-sponsors of the November 2008 UNGA
resolution on International Drug Control (A/63/432).
(viii)  Finally, that Department instruct U.S. Embassies Berlin,
Brussels, Paris, Dublin, Rome, and especially Stockholm (as well as
any other capital who may be more sympathetic to the need for
compromise) to underline the firmness of our position, and the
importance of finding common ground for the March ministerial
meeting.  Instructions should also note that Belgium, Ireland and
Italy co-sponsored the November 2008 UNGA resolution A/63/432.  In
particular, it should be noted that the current EU proposal
effectively eliminates the draft's previous focus on prevention,
treatment and rehabilitation.  Although there may be some
disagreement on "harm reduction," Mission believes all delegations
should be concerned that the elimination of prevention, treatment
and rehabilitation from their prominent place in the draft may give
the wrong signal that member states are no longer focusing on the
critical need to reduce the demand for drugs.
***

If you liked that, you’ll love the rest of Neuro­bonkers, so go and read it all. You can also follow him on twitter if you’re that way inclined.

Posted in Drugs | Tagged government, harm reduction, Vienna |

The Drugs

Sorry about the lack of updates — we’ve turned to the drugs.

[Video]

Posted in Drugs | Tagged addiction, the drugs, tv |

Intermission

Sorry about the lack of activity. We’ve been dead busy since the new year — Coffeesh0p’s had more orders for legal highs and such so far this year than for all of 2008, and I’ve been optim­ising like a bastard, among other things.

Hope­fully, I’ll write some­thing soon about what I’ve been up to when I’ve the time, but for now, here’s some music while you wait:

Posted in About This Site |